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inhibition of connexin 43 translocation on mitochondria

Aldo PINTO Publications

Toggle navigation.Menu.Aldo PINTOAuthor Jia-Dan Wang,Ying Shao,Dan Liu,Nuo-Ya Liu,Dan-Yan ZhuPublish Year 2021Doxorubicin-Mediated Cardiotoxicity Role ofrelated to mitochondrial dysfunction.Connexin 43 (Cx43),the Pharmacological inhibition of Hsp90 Translocation of Cx43 to mitochondria appears to beCardiac Mitochondrial Connexin 43 Regulates ApoptosisJan 05,2007·In the present study,we confirmed the presence of Cx43 immunoreactivity in the outer membrane of the mitochondria isolated from adult cardiac ventricles and provide evidence that mitochondrial Cx43 as a novel regulator of mitochondrial function where inhibition results in the release of cytochrome C and myocyte apoptosis.

Cardiac abnormalities after induction of endoplasmic

The free consultation period for this content is over.It is now only available year-round to ESC Professional Members,Fellows of the ESC,and Young combined MembersCells Free Full-Text Myocardial Adaptation in Mitochondrial connexin 43 is involved in the regulation process by inhibition of mPTP opening.These individual cardioprotective mechanisms can be interconnected in the process of mitochondrial oxidative phosphorylation resulting in the maintenance of adenosine triphosphate (ATP) production.Cited by 124Publish Year 2007Author Farida Goubaeva,Maya Mikami,Sarah Giardina,Bo Ding,Junichi Abe,Jay YangInteraction between Connexin 43 and nitric oxide synthase The mitochondrial nitric oxide formation was reduced in Cx43 CreER(T)/fl mitochondria (0.14 ± 0.02 nmol/min./mg protein) in comparison to wildtype mitochondria (0.24 ± 0.02 nmol/min./mg).These are the first data demonstrating,that a reduced mitochondrial Cx43 content is associated with a switch of the mitochondrial NOS isoform and the respective mitochondrial rate of nitric oxide formation.

Cited by 12Publish Year 2018Author Michela Pecoraro,Aldo Pinto,Ada PopoloInhibition of Connexin 43 translocation on mitochondria

·The inhibition of Cx43 translocation on mitochondria by Hsp90 inhibitor,significantly increases the effect of CoCl 2 by accelerating mitochondrial ROS production,especially afterCited by 12Publish Year 2018Author Michela Pecoraro,Aldo Pinto,Ada PopoloInhibition of Connexin 43 translocation on mitochondria CoCl 2 (50100150 M) was administered for 3 or 6 h,alone or combined with Radicicol,that inhibits Cx43 translocation on mitochondria,to demonstrate the crucial role of mitochondrial Cx43 in the cardioprotection.In fact,reduction of Cx43 translocation on mitochondria increases mitochondrial ROS production,cytosolic and mitochondrial calcium overload and mitochondrial membraneCited by 12Publish Year 2018Author Michela Pecoraro,Aldo Pinto,Ada PopoloInhibition of Connexin 43 translocation on mitochondria Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl2-induced apoptotic response in a chemical model of hypoxia.Pecoraro M (1),Pinto A (1),Popolo A (2).Author information (1)Department of Pharmacy,University of Salerno.Via Giovanni Paolo II,Fisciano,Salerno,Italy.

Cited by 12Publish Year 2018Author Michela Pecoraro,Aldo Pinto,Ada PopoloInhibition of Connexin 43 translocation on mitochondria

Request PDF Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl 2 -induced apoptotic response in a chemical model of hypoxia Hypoxia is the basis of many myocardial Cited by 12Publish Year 2018Author Michela Pecoraro,Aldo Pinto,Ada PopoloTranslocation of Connexin 43 to the Inner Mitochondrial We have previously shown that connexin 43 (Cx43) is present in mitochondria,that its genetic depletion abolishes the protection of ischemia- and diazoxide-induced preconditioning,and that it is involved in reactive oxygen species (ROS) formation in response to diazoxide.Cited by 1Publish Year 2020Author Michela Pecoraro,Barbara Pala,Maria Carmela Di Marcantonio,Raffaella Muraro,Stefania Marzocco,ATranslocation of Connexin 43 to the Inner Mitochondrial mechanism of Cx43 translocation to mitochondria and the effect of inhibiting translocation on the protection of preconditioning.Confocal microscopy of mitochondria devoid of the outer membrane and Western blotting on fractionated mitochondria showed that Cx43 is located at the inner mitochondrial membrane,and coimmunoprecipita-

Cited by 240Publish Year 2006Author Antonio Rodriguez-Sinovas,Kerstin Boengler,Alberto Cabestrero,Petra Gres,Miriam Morente,MarisolDoxorubicininduced oxidative and nitrosative stress

the mechanisms that further increase mitochondrial super-oxide generation (e.g.,the inhibition of c x43 translocation into the mitochondria) significantly accelerate the occurrence of cell death.Introduction connexin 43 ( cx43) is a major gap -junction protein that medi - ates intercellular communication by promoting the passageCited by 240Publish Year 2006Author Antonio Rodriguez-Sinovas,Kerstin Boengler,Alberto Cabestrero,Petra Gres,Miriam Morente,MarisolInhibition of Connexin 43 translocation on mitochondria Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl2-induced apoptotic response in a chemical model of hypoxia By Michela Pecoraro,Aldo Pinto and Ada Popolo CiteCited by 54Publish Year 2014Author Daniel Soetkamp,Daniel Soetkamp,Tiffany T.Nguyen,Sara Menazza,Christine Hirschhäuser,Ulrike B.Connexins a myriad of functions extending beyondConnexin 43 interacts preferentially with ZO-1 during G 0 stage,whereas the interaction with ZO-2 is approximately the same during the various stages 89.This may signify a greater level of complexity in the connexin-zonula occludens interactions and their impact on cellular functions.

Cited by 6Publish Year 2018Author Maria Shvedova,Yana Anfinogenova,Sergey V.Popov,Dmitriy N.Atochin,Dmitriy N.AtochinDoxorubicininduced oxidative and nitrosative stress

Furthermore,it is demonstrated that the mechanisms that further increase mitochondrial superoxide generation (e.g.,the inhibition of Cx43 translocation into the mitochondria) significantly accelerate the occurrence of cell death.Connexin 43 acts as a cytoprotective mediator of signal and the mitochondrial phosphoprotein(s) that mediate cytoprotection by PKC remain to be determined.As mice deficient in the main sarcolemmal gap junction protein connexin 43 (Cx43) lack this cytoprotec-tion,we set out to investigate a possible link among mitochondrial Cx43,mitoK ATP channel function,and PKC activation.Connexin 43 acts as a cytoprotective mediator of signal transgenic animals with connexin 43 deficiency (911).Connexin 43 (Cx43),the main gap junction protein,is predominantly localized in the sarcolemma but is also found in the inner mitochondrial membrane (Figure 1) (10,12).To determine how mitochondrial

Connexin 43 impacts on mitochondrial potassium uptake

In cardiomyocytes,connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane,but the protein is also present at the inner membrane of subsarcolemmal mitochondria (SSM).Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration.Since mitochondrial potassium influx impacts on oxygen Connexin 43 impacts on mitochondrial potassium uptakeIn cardiomyocytes,connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane,but the protein is also present at the inner membrane of subsarcolemmal mitochondria (SSM).Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration.Since mitochondrial potassium inux impacts onConnexin 43 impacts on mitochondrial potassiumIn cardiomyocytes,connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane,but the protein is also present at the inner membrane of subsarcolemmal mitochondria (SSM).Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration.Since mitochondrial potassium inux impacts on

Connexins and Nitric Oxide Inside and Outside Mitochondria

May 16,2018·Pharmacological inhibition of heat shock protein 90 (Hsp90) showed that the mitochondrial Cx43 exerts cardioprotective effects through attenuation of cytosolic and mitochondrial ROS production,mitochondrial Ca 2+ overload,mitochondrial membrane depolarization,and cytochrome c release (Pecoraro et al.,2015).In glioblastomas treatment,a Hsp90-dependent mitochondrialDoxorubicin-Mediated Cardiotoxicity Role of Mitochondrial Doxorubicin is the highly effective anthracycline,but its clinical use is limited by cardiotoxicity and consequent dysfunction.It has been proposed that the etiology of this is related to mitochondrial dysfunction.Connexin 43 (Cx43),the principal protein building block of cardiac gap junctions and hemichannels,plays an important role in cardioprotection.Doxorubicin-Mediated Cardiotoxicity Role of Mitochondrial Jan 01,2015·Doxorubicin is the highly effective anthracycline,but its clinical use is limited by cardiotoxicity and consequent dysfunction.It has been proposed that the etiology of this is related to mitochondrial dysfunction.Connexin 43 (Cx43),the principal protein building block of cardiac gap junctions and hemichannels,plays an important role in cardioprotection.Recent reports confirmed the

Doxorubicin-Mediated Cardiotoxicity Role of Mitochondrial

Our data show that Doxo translocation of Cx43 from cytosol to mitochondria with a induces a dose- and time-dependent increase in cytosolic mechanism that involves Hsp90/TOM 20 machinery sys- and mitochondrial oxygen radical species,as demonstrated temImages of Inhibition of Connexin 43 translocation On mitoch imagesTranslocation of connexin 43 to the inner mitochondrial We have previously shown that connexin 43 (Cx43) is present in mitochondria,that its genetic depletion abolishes the protection of ischemia- and diazoxide-induced preconditioning,and that it is involved in reactive oxygen species (ROS) formation in response to diazoxide.Here we investigated the intramitochondrial localization of Cx43,the mechanism of Cx43 translocation to mitochondria and the effect of inhibiting translocation on the protection of preconditioning.Inhibition of Connexin 43 translocation on mitochondria accelerates CoCl2-induced apoptotic responsein a chemical model of hypoxiaAuthor:Michela Pecoraro,Aldo Pinto,Ada PopoloCited by:12Publish Year:2018Inhibition of Connexin 43 translocation on mitochondria Was this helpful?Inhibition of Connexin 43 translocation on mitochondria CoCl 2 (50-100-150M) was administered for 3 or 6h,alone or combined with Radicicol,that inhibits Cx43 translocation on mitochondria,to demonstrate the crucial role of mitochondrial Cx43 in the cardioprotection.In fact,reduction of Cx43 translocation on mitochondria increases mitochondrial ROS production,cytosolic and mitochondrial calcium overload and mitochondrial membrane

Inhibition of permeability transition pore opening by

Oct 20,2010·Rodriguez-Sinovas A,Boengler K,Cabestrero A,Gres P,Morente M,Ruiz-Meana M,Konietzka I,Miró E,Totzeck A,Heusch G,Schulz R,Garcia-Dorado D (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection.Mitochondrial Fate of Regenerative Hematopoietic Stem ·Abhishek K Singh,Karin Golan,Mark J Althoff,Ekaterina Petrovich-Kopitman,Ashley M Wellendorf,Fatima Mohmoud,Mayla Bertagna,Daniel Gonzalez-Nieto,Luis C Barrio,Tsvee Lapidot,Jose A Cancelas; Connexin-43 Is a Negative Regulator of Mitochondrial Fission,Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis.Mitochondrial connexin 43 impacts on respiratory complex I Dec 30,2011·Abstract Connexin 43 (Cx43) is present at the sarcolemma and the inner membrane of cardiomyocyte subsarcolemmal mitochondria (SSM).Lack or inhibition of mitochondrial Cx43 is associated with reduced mitochondrial potassium influx,which might affect mitochondrial respiration.

Mitochondrial connexin 43 impacts on respiratory complex

Connexin 43 (Cx43) is present at the sarcolemma and the inner membrane of cardiomyocyte subsarcolemmal mitochondria (SSM).Lack or inhibition of mitochondrial Cx43 is associated with reduced mitochondrial potassium influx,which might affect mitochondrial respiration.Therefore,we analysed the importance of mitochondrial Cx43 for oxygen Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels pivotal roles in hemichannel-mediated cell injury Yuan Chi1, inhibition of P2 purinoceptors but counteracted by exogenous ATP. (an inhibitor of mitochondrial electron transport) and iodoacetic acid (an inhibitor of glycolysis).As expected,these chemicals caused aRegulation of mitochondrial functions by protein Apr 14,2016·The mechanism of GSK3s translocation to the mitochondria is unclear,but TOM20 may be integral,as in the example of connexin-43 .In mitochondria,GSK3 phosphorylates and suppresses a critical mitochondrial enzyme,pyruvate dehydrogenase activity [ 74 ].

Related searches for inhibition of connexin 43 translocatio

connexin 43 geneconnexin 43 antibody12345NextTranslocation of Connexin 43 to the Inneris transported to the inner mitochondrial membrane through translocation via the TOM complex and that a normal mitochondrial Cx43 content is important for the diazoxide-related pathway of preconditioning.(Circ Res.2006;99:93-101.) Key Words mitochondria heat shock protein geldanamycin connexin 43 TOM (Translocase of the Outer Membrane) complex CRelated searches for inhibition of connexin 43 translocatioconnexin 43 geneconnexin 43 antibodyRictor/mTORC2 involves mitochondrial function in ES cells Feb 05,2021·As a result,in ESC-CMs,the increased acetylation of Hsp90 mediated by HDAC6 inhibition disturbed Cx43 translocation.These results suggested that knockdown of Rictor could interfere with the

Rictor/mTORC2 involves mitochondrial function in ES cells

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43.1 Coronavirus Find the latest articles and preprintsS-nitrosation of mitochondrial connexin 43 regulates The absence or phar- macological blockade of mitochondrial Cx43 (mtCx43) reduces dye and potassium uptake.Lack of mtCx43 is associated with loss of endogenous cardioprotection by ischemic preconditioning (IPC),which is mediated by formation of reactive oxygen species (ROS).Search Articles University of Toronto LibrariesUofT Libraries is getting a new library services platform in January 2021.Learn more about the change.

Stimulation of cardiac adrenoceptors targets connexin 43

Aug 25,2009·Connexin 43 (Cx43) is the major protein of cardiac ventricular gap junctions and is crucial to cellcell communication and cardiac function.The protein level of Cx43 is reduced in patients with heart failure or dilated cardiomyopathy (DCM),pathophysiological conditions oftenThe Role of Mitochondrial Functional Proteins in ROS A.Rodriguez-Sinovas,K.Boengler,A.Cabestrero et al.,Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection, Circulation Research,vol.99,no.1,pp.93101,2006.View at Publisher Site Google ScholarThe role of hexokinase in cardioprotection mechanism and Sep 10,2014·This was not accompanied by any translocation of PKs such as PKC and GSK3 to mitochondria or detectable changes in phosphorylation of any mitochondrial protein (Clarke et al.,2008).Nor did we observe IPinduced translocation of connexin 43 to mitochondria (Halestrap et al .,2007 ),which had previously been described by others

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